Developmental dysplasia of the hip may predispose to osteoarthritis: From inflammation to destruction. A literature review

Authors

  • Jorge Alvarado-García Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Hospital Regional de Puebla, Trauma and Orthopedics Service, Puebla, Mexico. https://orcid.org/0000-0002-7733-8400
  • Liliana García-Ortiz Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Genomic Medicine Division, Mexico City, Mexico. https://orcid.org/0000-0003-1629-6128
  • José Gutiérrez-Salinas Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, Biomedical Research Division, Biochemistry and Experimental Medicine Laboratory, Ciudad de México, México. https://orcid.org/0000-0002-9605-6097
  • Tanía Jazmín Ruiz-Sánchez Universidad Nacional Autónoma de México, Cuautitlán School of Higher Education, Undergraduate Program in Diagnostic Biochemistry, State of Mexico, Mexico. https://orcid.org/0000-0002-0166-9019

DOI:

https://doi.org/10.58814/01208845.19

Keywords:

Development Dysplasia of the Hip, Osteoarthritis, Genes, Inflammation

Abstract

Introduction: Developmental dysplasia of the hip (DDH) encompasses a set of abnormalities related to the maturation process of the acetabulum and the proximal third of the femur. If not treated properly and promptly, patients with this condition may eventually develop osteoarthritis (OA).

Objective: To compile and synthesize scientific evidence published between January 2000 and February 2023 on the pathophysiology of DDH and its relationship to the development of hip OA in terms of genetic, inflammatory and immunological pathophysiological mechanisms.

Methodology: A literature review was performed in biomedical literature databases (PubMed/Medline, Embase, SciELO) and bioinformatic resources (e-Ensambl, STRING), using terms such as "hip dysplasia", "osteoarthritis", "etiology", and "genes". Clinical and genetic observational studies involving human subjects were included.

Results: The initial search yielded 349 records, of which 23 met the eligibility criteria. Genes that interact with genetic modules may play a role in the development of joints and the etiology of diseases that affect the bones and cartilage; however, the mechanical instability caused by DDH activates inflammatory and immunological factors, predisposing to OA. Based on the information obtained, it is possible to consider that there is a very close relationship between DDH and OA.

Conclusions: Knowing the genetic, inflammatory and immunological pathophysiological mechanisms of DDH and OA favors timely diagnosis and, consequently, allows providing proper treatment to reduce and control long-term damage and improve the patient's quality of life.

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Published

2023-06-30

How to Cite

1.
Alvarado-García J, García-Ortiz L, Gutiérrez-Salinas J, Ruiz-Sánchez TJ. Developmental dysplasia of the hip may predispose to osteoarthritis: From inflammation to destruction. A literature review. Rev. Colomb. Ortop. Traumatol. [Internet]. 2023 Jun. 30 [cited 2025 May 16];37(2):e19. Available from: https://revistasccot.org/index.php/rccot/article/view/19

Issue

Vol. 37 No. 2 (2023)

Section

Original research

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