Prevalence of fractures in children with Cerebral Palsy. Cross-sectional Cohort Study

Authors

  • Hernando Gaitán-Lee Pontificia Universidad Javeriana. Bogotá, Colombia
  • Carlos Alberto Sánchez-Correa Pontificia Universidad Javeriana. Bogotá, Colombia
  • Daniel Torres-Mejía Universidad de Cartagena. Cartagena, Colombia
  • Manuela Quiroga-Carrillo Instituto Roosevelt. Bogotá, Colombia
  • José Luis Duplat-Lapides Instituto Roosevelt. Bogotá, Colombia
  • Mónica Cediel-Echeverry Instituto Roosevelt. Bogotá, Colombia

DOI:

https://doi.org/10.1016/j.rccot.2021.02.013

Keywords:

cerebral palsy, fracture, prevalence, Children, children

Abstract

Background: Cerebral palsy (CP) is a group of non-progressive movement and posture disorders that occurs as a result of an injury to the brain during development. It is associated with fractures mainly affecting the supracondylar region of the femur. The general objective of thestudy was to determine the prevalence of fractures in children with CP at the Roosevelt Institute between January and December 2017.
Methods: A descriptive cross-sectional study was carried out taking as variables age, sex, functional level (GMFCS), use of anticonvulsants and presence of gastrostomy, defining the outcome as the presence of fracture.
Results: 648 patients with cerebral palsy were identified, within which a total of 5 patients presented fractures for a calculated prevalence of 0.0187, all were located in the supracondylar region of the femur. Two patients (40%) received orthopedic management and three patients (60%) surgical management with osteosynthesis. Two patients (40%) presented GMFCS I, 1 patient (20%) GMFCS II and 2 patients (40%) GMFCS V. No patient had a gastrostomy or received anticonvulsants.
Discussion: The incidence of fractures in the study population was lower than that reported in the literature, the supracondylar region of the femur was the most affected in the present study, without complications during follow-up. No association with gastrostomy or use of anticonvulsants was identified.
Evidence Level: III

Downloads

Download data is not yet available.

Author Biographies

Hernando Gaitán-Lee, Pontificia Universidad Javeriana. Bogotá, Colombia

Residente Ortopedia y Traumatología, Pontificia Universidad Javeriana, Bogotá, Colombia.

Carlos Alberto Sánchez-Correa, Pontificia Universidad Javeriana. Bogotá, Colombia

Residente Ortopedia y Traumatología, Pontificia Universidad Javeriana, Bogotá, Colombia.

Daniel Torres-Mejía, Universidad de Cartagena. Cartagena, Colombia

Residente Ortopedia y Traumatología, Universidad de Cartagena, Cartagena, Colombia.

Manuela Quiroga-Carrillo, Instituto Roosevelt. Bogotá, Colombia

Instituto Roosevelt, Bogotá, Colombia.

José Luis Duplat-Lapides, Instituto Roosevelt. Bogotá, Colombia

Ortopedista Infantil, Instituto Roosevelt, Bogotá, Colombia.

Mónica Cediel-Echeverry, Instituto Roosevelt. Bogotá, Colombia

Pediatra, Instituto Roosevelt, Bogotá, Colombia.

References

Nazif H, Shatla R, Elsayed R, Tawfik E, Osman N, Korra S, et al. Bone mineral density and insulin-like growth factor-1 in children with spastic cerebral palsy. Child's Nerv Syst. 2017;33:625-30. https://doi.org/10.1007/s00381-017-3346-9

Bax M, Goldstein M, Rosenbaum P, Leviton A, Paneth N, Dan B, Jacobsson B, Damiano D. Executive Committee for the Definition of Cerebral Palsy.Proposed definition and classification of cerebral palsy. Dev Med Child Neurol. 2005;47:571-6, https://doi.org/10.1017/S001216220500112X

Kilpinen-Loisa P, Pihko H, Vesander U, Paganus A, Ritanen U, Mäkitie O. Insufficient energy and nutrient intake in children with motor disability. Acta Paediatr Int J Paediatr. 2009;98:1329-33. https://doi.org/10.1111/j.1651-2227.2009.01340.x

Aronson E, Stevenson SB. Bone Health in Children With Cerebral Palsy and Epilepsy. J Pediatr Heal Care. 2012;26:193-9, https://doi.org/10.1016/j.pedhc.2010.08.008

Finbråten AK, Syversen U, Skranes J, Andersen GL, Stevenson RD, Vik T. Bone mineral density and vitamin D status in ambulatory and non-ambulatory children with cerebral palsy. Osteoporos Int. 2014;26:141-50. https://doi.org/10.1007/s00198-014-2840-0

Tosun A, Erisen Karaca S, Unuvar T, Yurekli Y, Yenisey C, Omurlu IK. Bone mineral density and vitamin D status in children with epilepsy, cerebral palsy, and cerebral palsy with epilepsy. Child's Nerv Syst. 2017;33:153-8, https://doi.org/10.1007/s00381-016-3258-0

Tasdemir H, Buyukavci M, Akcay F, Polat P, Yildiran A, Karakelleoglu C. Bone mineral density in children with cerebral palsy. Pediatr Int. 2001;43:157-60. https://doi.org/10.1046/j.1442-200x.2001.01352.x

Presedo A, Dabney KW, Miller F. Fractures in patients with cerebral palsy. J Pediatr Orthop. 2007;27:147-53. https://doi.org/10.1097/BPO.0b013e3180317403

Bischof F, Basu D, Pettifor J. Pathological long-bone fractures in residents with cerebral palsy in a long-term care facility in South Africa. Dev Med Child Neurol. 2002;44:119-22. https://doi.org/10.1111/j.1469-8749.2002.tb00297.x

Leet A, Mesfin A, Pichard C, Launay F, BrintzenhofeSzoc K, Levey E, et al. Pathologic fractures in children with cerebral palsy. J Pediatr Orthop. 2006;26:624-7. https://doi.org/10.1097/01.bpo.0000235228.45539.c7

Mughal MZ. Fractures in children with cerebral palsy. Curr Osteoporos Rep. 2014;12:313-8. https://doi.org/10.1007/s11914-014-0224-1

Le Roy C, Meier M, Witting S, Pérez-Bravo F, Solano C, Castillo- Durán C. Effect of supplementation with a single dose of Vitamin D in children with cerebral palsy. Preliminary randomised controlled study. Rev Chil Pediatr. 2015;86:393-8, https://doi.org/10.1016/j.rchipe.2015.07.015

Jekovec-Vrhovˇsek M, Kocijanˇciˇc A, Preˇzelj J. Effect of Vitamin D and calcium on bone mineral density in children with CP and epilepsy in full-time care. Dev Med Child Neurol. 2000;42:403-5. https://doi.org/10.1111/j.1469-8749.2000.tb00119.x

Kilpinen-Loisa P, Nenonen H, Pihko H, Mäkitie O. High-dose vitamin D supplementation in children with cerebral palsy or neuromuscular disorder. Neuropediatrics. 2007;38:167-72. https://doi.org/10.1055/s-2007-990266

Stevenson R, Conaway M, Barrington J, Cuthill S, Worley G, Henderson R. Fracture rate in children with cerebral palsy. Pediatr Rehabil. 2006;9:396-403. https://doi.org/10.1080/13638490600668061

Brunner R, Doderlein L. Pathological fractures in patients with cerebral palsy. J Pediatr Orthop B. 1996;5:232-8. https://doi.org/10.1097/01202412-199605040-00003

Henderson RC, Kairalla J, Abbas A, Stevenson RD. Predicting low bone density in children and young adults with quadriplegic cerebral palsy. Dev Med Child Neurol. 2004;46:416-9. https://doi.org/10.1017/S0012162204000672

Ozel S, Switzer L, Macintosh A, Fehlings D. Informing evidencebased clinical practice guidelines for children with cerebral palsy at risk of osteoporosis: an update. Dev Med Child Neurol. 2016;58:918-23. https://doi.org/10.1111/dmcn.13196

Mergler S, Evenhuis HM, Boot AM, De Man SA, Heus KGCBB, De, Huijbers WAR, et al. Epidemiology of low bone mineral density and fractures in children with severe cerebral palsy: A systematic review. Dev Med Child Neurol. 2009;51:773-8. https://doi.org/10.1111/j.1469-8749.2009.03384.x

Henderson R. Bone density and other possible predictors of fracture risk in children and adolescents with spastic quadriplegia. Dev Med Child Neurol. 1997;39:24-7. https://doi.org/10.1111/j.1469-8749.1997.tb07415.x

Henderson RC, Lark RK, Kecskemethy HH, Miller F, Harcke HT, Bachrach SJ. Bisphosphonates to treat osteopenia in children with quadriplegic cerebral palsy: A randomized, placebocontrolled clinical trial. J Pediatr. 2002;141:644-51. https://doi.org/10.1067/mpd.2002.128207

Ya ̧sarE,AdigüzelE,ArslanM,MatthewsDJ.Basicsofbone metabolism and osteoporosis in common pediatric neuromuscular disabilities. Eur J Paediatr Neurol. 2018;22:17-26, https://doi.org/10.1016/j.ejpn.2017.08.001

Dussault PM, Lazzari AA. Epilepsy and osteoporosis risk. Curr Opin Endocrinol Diabetes Obes. 2017;24:395-401. https://doi.org/10.1097/MED.0000000000000366

Paksu MS, Vurucu S, Karaoglu A, Karacalioglu AO, Polat A, Yesilyurt O, et al. Osteopenia in children with cerebral palsy can be treated with oral alendronate. Child's Nerv Syst. 2012;28:283-6. https://doi.org/10.1007/s00381-011-1576-9

Chen CL, Chen CY, Liaw MY, Chung CY, Wang CJ, Hong WH. Efficacy of home-based virtual cycling training on bone mineral density in ambulatory children with cerebral palsy. Osteoporos Int. 2013;24:1399-406. https://doi.org/10.1007/s00198-012-2137-0

Gannotti ME, Breive EL, Miller K, Mobyed R, Cameron RA. Exercise programs designed and dosed to improve bone mineral density in children with cerebral palsy. Crit Rev Phys Rehabil Med. 2016;28:283-304. https://doi.org/10.1615/CritRevPhysRehabilMed.v28.i4.50

Harcke HT, Stevenson KL, Kecskemethy HH, Bachrach SJ, Grissom LE. Fracture after bisphosphonate treatment in children with cerebral palsy: The role of stress risers. Pediatr Radiol. 2012;42:76-81. https://doi.org/10.1007/s00247-011-2198-9

Published

2021-04-08

How to Cite

1.
Gaitán-Lee H, Sánchez-Correa CA, Torres-Mejía D, Quiroga-Carrillo M, Duplat-Lapides JL, Cediel-Echeverry M. Prevalence of fractures in children with Cerebral Palsy. Cross-sectional Cohort Study. Rev. colomb. ortop traumatol. [Internet]. 2021 Apr. 8 [cited 2024 May 19];35(2):164-8. Available from: https://revistasccot.org/index.php/rccot/article/view/173

Issue

Section

Original research
QR Code
Crossref Cited-by logo

Some similar items: