Manejo quirúrgico de tumor pardo en metacarpo. Reporte de caso

Autores/as

  • Marco Antonio Altamirano-Cruz Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México
  • Diego Fernando Tovar-Cortés Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México
  • Simon Quetzalcóatl Rodriguez-Lara Universidad de Guadalajara, Guadalajara, Jalisco, México
  • Leonardo Xicotencatl Gutierrez-Ramírez Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México

DOI:

https://doi.org/10.1016/j.rccot.2020.04.014

Palabras clave:

tumor pardo, manejo quirúrgico, peroné no vascularizado, injerto óseo

Resumen

El tumor pardo, también conocido como osteoclastoma ó como osteítis fibrosa quística, es un tumor lítico, que se presenta en hiperparatiroidismo (primario, secundario y terciario), aunque su presentación habitual es altamente invasiva, no tiene potencial de malignidad. Los tumores pardos en la mano son muy poco frecuentes y existen solo algunos reportes de casos. Presentamos un paciente masculino de 18 años con una tumoración dura, no móvil, adherida a planos profundos en región dorsal de la mano derecha sobre el cuarto metacarpiano, que además limita la flexión y extensión del cuarto dedo sin alterar su función neurovascular. El paciente fue sometido a resección de la tumoración que involucraba por completo al cuarto metacarpiano derecho, además se realizó un abordaje lateral directo en miembro pelvico izquierdo para tomar un injerto autólogo de peroné no vascularizado. Es importante la detección temprana de este tipo de tumores y se debe dar un adecuado seguimiento, ya que, al progresar, generan una destrucción ósea importante y el tratamiento se vuelve de mayor complejidad. En etapas tempranas, el manejo agresivo con resección y aporte óseo puede evitar secuelas funcionales. El uso de injerto no vascularizado de peroné de seis centímetros para la sustitución del cuarto metacarpiano por osteolísis secundaria a un tumor pardo es una alternativa adecuada de tratamiento que permite la preservación estético funcional de la mano.

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Biografía del autor/a

Marco Antonio Altamirano-Cruz, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México

Unidad Medica de Alta Especialidad, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social. Médico Adscrito al Departamento de Traumatología y Ortopedia. Guadalajara, Jalisco, México.

Diego Fernando Tovar-Cortés, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México

Unidad Medica de Alta Especialidad, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social. Médico Residente de segundo ano˜ de Traumatología y Ortopedia. Guadalajara, Jalisco, México.

Simon Quetzalcóatl Rodriguez-Lara, Universidad de Guadalajara, Guadalajara, Jalisco, México

Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara Doctor en Farmacología, Departamento de Fisiología. Guadalajara, Jalisco, México.

Leonardo Xicotencatl Gutierrez-Ramírez, Instituto Mexicano del Seguro Social. Guadalajara, Jalisco, México

Unidad Medica de Alta Especialidad, Centro Medico Nacional de Occidente, Instituto Mexicano del Seguro Social. Jefe de servicio de Traumatología y Ortopedia. Guadalajara, Jalisco, México.

Referencias bibliográficas

Bahrami E, Alireza T, Ebrahim H, Mohammadreza S. Maxillary and orbital brown tumor of primary hyperparathyroidism. The American journal of case reports. 2012;13:183. https://doi.org/10.12659/AJCR.883325

Damjanov I, Linder J. Anderson's Pathology-Vol 1. 10th ed. Ayala AG RJ, Raymond AK, editor: Mosby; 1996.

Griffiths HJ, Ennis JT, Bailey G. Skeletal changes following renal transplantation. Radiology. 1974;113:621-6. https://doi.org/10.1148/113.3.621

Irie T, Mawatari T, Ikemura S, Matsui G, Iguchi T, Mitsuyasu H. Brown tumor of the patella caused by primary hyperparathyroidism: a case report. Korean journal of radiology. 2015;16: 613-6. https://doi.org/10.3348/kjr.2015.16.3.613

Massry SG, Ritz E. The pathogenesis of secondary hyperparathyroidism of renal failure: Is there a controversy? Archives of internal medicine. 1978;138 Suppl 5:853-6. https://doi.org/10.1001/archinte.138.Suppl_5.853

Pérez-Guillermo M, Acosta-Ortega J, García-Solano J, RamosFreixá J. Cytologic aspect of brown tumor of hyperparathyroidism Report of a case affecting the hard palate. Diagnostic cytopathology. 2006;34:291-4. https://doi.org/10.1002/dc.20434

Etemadi J, Mortazavi-Khosrowshahi M, Ardalan M, Esmaili H, Javadrashid R, Shoja M. editors. Brown tumor of hyperparathyroidism masquerading as central giant cell granuloma in a renal transplant recipient: a case report. Transplantation proceedings;. 2009. Elsevier. https://doi.org/10.1016/j.transproceed.2009.07.040

Nassar GM, Ayus JC. Brown tumor in end-stage renal disease. The New England Journal of Medicine. 1999;341:1652. https://doi.org/10.1056/NEJM199911253412204

Resic H, Masnic F, Kukavica N, Spasovski G. Unusual clinical presentation of brown tumor in hemodialysis patients: two case reports. International urology and nephrology. 2011;43:575-80. https://doi.org/10.1007/s11255-010-9738-3

Feldman F. Primary bone tumors of the hand and carpus. Hand clinics. 1987;3:269-89. https://doi.org/10.1016/S0749-0712(21)00658-2

Rossi B, Ferraresi V, Appetecchia M, Novello M, Zoccali C. Giant cell tumor of bone in a patient with diagnosis of primary hyperparathyroidism: a challenge in differential diagnosis with brown tumor. Skeletal Radiology. 2014;43(5.). https://doi.org/10.1007/s00256-013-1770-9

Su AW, Chen C-F, Huang C-K, Chen PC-H, Chen W-M, Chen TH. Primary hyperparathyroidism with brown tumor mimicking metastatic bone malignancy. Journal of the Chinese Medical Association. 2010;73:177-80. https://doi.org/10.1016/S1726-4901(10)70035-6

Germann G, Wind G, Harth A. The DASH (Disability of ArmShoulder-Hand) Questionnaire-a new instrument for evaluating upper extremity treatment outcome. Handchirurgie, Mikrochirurgie, plastische Chirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft fur Handchirurgie: Organ der Deutschsprachigen Arbeitsgemeinschaft fur Mikrochirurgie der Peripheren Nerven und Gefasse: Organ der V. 1999;31:149-52.

Al-Sharafi BA, Al-Imad SA, Shamshair AM, Al-Faqeeh DH. Brown tumours of the tibia and second metacarpal bone in a woman with severe vitamin D deficiency. BMJ case reports. 2015, bcr2014207722. https://doi.org/10.1136/bcr-2014-207722

Altay C, Erdo˘gan N, Eren E, Altay S, Karasu ¸,S Uluc¸ E. Computed tomography findings of an unusual maxillary sinus mass: brown tumor due to tertiary hyperparathyroidism. Journal of clinical imaging science. 2013:3. https://doi.org/10.4103/2156-7514.122325

Hussain M, Hammam M. Management challenges with brown tumor of primary hyperparathyroidism masked by severe vitamin D deficiency: a case report. Journal of medical case reports. 2016;10:166. https://doi.org/10.1186/s13256-016-0933-4

Fan Y, Hanai J-i, Le PT, Bi R, Maridas D, DeMambro V, et al. Parathyroid hormone directs bone marrow mesenchymal cell fate. Cell metabolism. 2017;25:661-72. https://doi.org/10.1016/j.cmet.2017.01.001

Silva BC, Bilezikian JP. Parathyroid hormone: anabolic and catabolic actions on the skeleton. Current opinion in pharmacology. 2015;22:41-50. https://doi.org/10.1016/j.coph.2015.03.005

Campbell EJ, Campbell GM, Hanley DA. The effect of parathyroid hormone and teriparatide on fracture healing. Expert opinion on biological therapy. 2015;15:119-29. https://doi.org/10.1517/14712598.2015.977249

Kong J, Qiao G, Zhang Z, Liu SQ, Li YC. Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium. Kidney international. 2008;74:1577-81. https://doi.org/10.1038/ki.2008.452

Stanbury S. The role of vitamin D in renal bone disease. Clinical endocrinology. 1977;7(s1.). https://doi.org/10.1111/j.1365-2265.1977.tb03358.x

Erturk E, Keskin M, Ersoy C, Kaleli T, Imamoglu S, Filiz G. Metacarpal brown tumor in secondary hyperparathyroidism due to vitamin-D deficiency: a case report. JBJS. 2005;87:1363-6. https://doi.org/10.2106/00004623-200506000-00026

Tarrass F, Ayad A, Benjelloun M, Anabi A, Ramdani B, Benghanem MG, et al. Cauda equina compression revealing brown tumor of the spine in a long-term hemodialysis patient. Joint Bone Spine. 2006;73:748-50. https://doi.org/10.1016/j.jbspin.2006.01.011

Pavlovic S, Valyi-Nagy T, Profirovic J, David O. Fine-needle aspiration of brown tumor of bone: Cytologic features with radiologic and histologic correlation. Diagnostic cytopathology. 2009;37:136-9. https://doi.org/10.1002/dc.20974

Verma P, Verma KG, Verma D, Patwardhan N. Craniofacial brown tumor as a result of secondary hyperparathyroidism in chronic renal disease patient: A rare entity. Journal of oral and maxillofacial pathology: JOMFP. 2014;18:267. https://doi.org/10.4103/0973-029X.140779

Gedik G, Ata O, Karabagli P, Sari O. Differential diagnosis between secondary and tertiary hyperparathyroidism in a case of a giant-cell and brown tumor containing mass. Findings by (99m) Tc-MDP,(18) F-FDG PET/CT and (99m) Tc-MIBI scans. Hellenic journal of nuclear medicine. 2014;17:214.

Yadav J, Madaan P, Jain V. Brown tumor due to vitamin D deficiency in a child with cerebral palsy. The Indian Journal of Pediatrics. 2014;81:1419-20. https://doi.org/10.1007/s12098-014-1517-1

Salem K, Brown CO, Schibler J, Goel A. Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-B activity. Exp Hematol. 2013:41. https://doi.org/10.1016/j.exphem.2012.10.002

Brown NJ. Contribution of aldosterone to cardiovascular and renal inflammation and fibrosis. Nature Reviews Nephrology. 2013;9:459-69. https://doi.org/10.1038/nrneph.2013.110

Pechalova PF, Poriazova EG. Brown tumor at the jaw in patients with secondary hyperparathyroidism due to chronic renal failure. Acta Medica (Hradec Kralove). 2013;56:83-6. https://doi.org/10.14712/18059694.2014.29

Artul S, Bowirrat A, Yassin M, Armaly Z. Maxillary and frontal bone simultaneously involved in brown tumor due to secondary hyperparathyroidism in a hemodialysis patient. Case reports in oncological medicine. 2013:2013. https://doi.org/10.1155/2013/909150

Mantar F, Gunduz S, Gunduz U. A reference finding rarely seen in primary hyperparathyroidism: brown tumor. Case reports in medicine. 2012:2012. https://doi.org/10.1155/2012/432676

Fish R, Danneman PJ, Brown M, Karas A. Anesthesia and analgesia in laboratory animals:. Academic Press; 2011.

Mateo L, Massuet A, Solà M, Andrés RP, Musulen E, Torres MCS. Brown tumor of the cervical spine: a case report and review of the literature. Clinical rheumatology. 2011;30:419-24. https://doi.org/10.1007/s10067-010-1608-y

Meng Z, Zhu M, He Q, Tian W, Zhang Y, Jia Q, et al. Clinical implications of brown tumor uptake in whole-body 99mTcsestamibi scans for primary hyperparathyroidism. Nuclear medicine communications. 2011;32:708-15. https://doi.org/10.1097/MNM.0b013e328347b582

Hong WS, Sung MS, Chun K-A, Kim J-Y, Park S-W, Lee K-H, et al. Emphasis on the MR imaging findings of brown tumor: a report of five cases. Skeletal radiology. 2011;40:205-13. https://doi.org/10.1007/s00256-010-0979-0

Jakubowski JM, Velez I, McClure SA. Brown tumor as a result of hyperparathyroidism in an end-stage renal disease patient. Case reports in radiology. 2011;2011:2011, 415476. doi: 10.1155/2011/415476. https://doi.org/10.1155/2011/415476

Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell metabolism. 2010;12:662-7. https://doi.org/10.1016/j.cmet.2010.11.015

Brown NJ. Aldosterone and vascular inflammation. Hypertension. 2008;51:161-7. https://doi.org/10.1161/HYPERTENSIONAHA.107.095489

Treglia G, Dambra DP, Bruno I, Mulè A, Giordano A. Costal brown tumor detected by dual-phase parathyroid imaging and SPECTCT in primary hyperparathyroidism. Clinical nuclear medicine. 2008;33:193-5. https://doi.org/10.1097/RLU.0b013e318162dd89

Khalil P, Heining S, Huss R, Ihrler S, Siebeck M, Hallfeldt K, et al. Natural history and surgical treatment of brown tumor lesions at various sites in refractory primary hyperparathyroidism. European journal of medical research. 2007;12:222.

Cebesoy O, Karakok M, Arpacioglu O, Baltaci E. Brown tumor with atypical localization in a normocalcemic patient. Archives of Orthopaedic & Trauma Surgery. 2007;127:577-80. https://doi.org/10.1007/s00402-007-0302-2

Diamanti-Kandarakis E, Livadas S, Tseleni-Balafouta S, Lyberopoulos K, Tantalaki E, Palioura H, et al. Brown tumor of the fibula: unusual presentation of an uncommon manifestation Report of a case and review of the literature. Endocrine. 2007;32:345-9. https://doi.org/10.1007/s12020-008-9035-4

Araki K, Masaki T, Katsuragi I, Tanaka K, Kakuma T, Yoshimatsu H. Telmisartan prevents obesity and increases the expression of uncoupling protein 1 in diet-induced obese mice. Hypertension. 2006;48:51-7. https://doi.org/10.1161/01.HYP.0000225402.69580.1d

Takeshita T, Takeshita K, Abe S, Takami H, Imamura T, Furui S. Brown tumor with fluid-fluid levels in a patient with primary hyperparathyroidism: radiological findings. Radiation medicine. 2006;24:631-4. https://doi.org/10.1007/s11604-006-0068-4

Brown DA, Lynch JM, Armstrong CJ, Caruso NM, Ehlers LB, Johnson MS, et al. Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat. The Journal of physiology. 2005;564:619-30. https://doi.org/10.1113/jphysiol.2004.081323

Brown NJ. Aldosterone and end-organ damage. Current opinion in nephrology and hypertension. 2005;14:235-41. https://doi.org/10.1097/01.mnh.0000165889.60254.98

Fernandez J, Anton I, Costas A. Brown tumor of the mandible as first manifestation of primary hyperparathyroidism: diagnosis and treatment. Medicina oral, patología oral y cirugía bucal. 2005;10:169-72.

Dursun H, Küc¸ükosmanoglu O, Noyan A, Özbarlas N, Büyükc¸elik M, Soran M, et al. Mitral annular calcification and brown tumor of the rib in a child with chronic renal failure. Pediatric Nephrology. 2005;20:673-5. https://doi.org/10.1007/s00467-004-1721-8

Bours V, Franzoso G, Azarenko V, Park S, Kanno T, Brown K, et al. The oncoprotein Bcl-3 directly transactivates through kappa B motifs via association with DNA-binding p50B homodimers. Cell. 1993;72:729-39. https://doi.org/10.1016/0092-8674(93)90401-B

Franzoso G, Bours V, Azarenko V, Park S, Tomita-Yamaguchi M, Kanno T, et al. The oncoprotein Bcl-3 can facilitate NFkappa B-mediated transactivation by removing inhibiting p50 homodimers from select kappa B sites. EMBO J. 1993;12: 3893-901. https://doi.org/10.1002/j.1460-2075.1993.tb06067.x

Chew F, Huang-Hellinger F. Brown tumor. AJR American journal of roentgenology. 1993;160:752. https://doi.org/10.2214/ajr.160.4.8456657

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2020-05-23

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1.
Altamirano-Cruz MA, Tovar-Cortés DF, Rodriguez-Lara SQ, Gutierrez-Ramírez LX. Manejo quirúrgico de tumor pardo en metacarpo. Reporte de caso. Rev. colomb. ortop traumatol. [Internet]. 23 de mayo de 2020 [citado 18 de mayo de 2024];34(1):74-81. Disponible en: https://revistasccot.org/index.php/rccot/article/view/237

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