Prognostic factors and return to sport rates after medial opening wedge high tibial osteotomy: systematic review
DOI:
https://doi.org/10.58814/01208845.741Keywords:
Osteotomy, Return to Sport, Prognosis, Knee Osteoarthritis, Systematic ReviewAbstract
Introduction: Medial opening wedge high tibial osteotomy is a joint-preserving procedure for active patients with medial unicompartmental knee osteoarthritis. Return to sport is a key outcome, but reported return-to-sport rates are heterogeneous and the prognostic factors remain poorly defined.
Objective: To synthesize the evidence on return-to-sport rates and prognostic factors in adults with medial unicompartmental knee osteoarthritis and varus deformity.
Methodology: A systematic search was conducted from January 2009 to June 2025 in accordance with the PRISMA 2020 and the CHARMS framework. Methodological quality was assessed using the QUIPS. Data were synthesized using a structured narrative synthesis, and the certainty was assessed using the GRADE approach for prognosis.
Results: Eleven studies (859 patients) were included. The rate of return to any level of sporting activity ranged from 73.9% to 88.6%, whereas return to the same preoperative level of sport was less frequent and more variable (34.6% to 50.0%). The mean time to return ranged from five to nine months. The prognostic factor with the strongest evidence was the preoperative level of sporting activity. Age, body mass index, and sex showed no consistent association. The certainty was low to very low for all prognostic factors.
Conclusions: Medial opening wedge high tibial osteotomy is associated with high rates of return to sporting activity, while return to the same preoperative level is less common. The evidence is of low certainty, and preoperative counseling should be undertaken with caution. Further prospective studies are needed.
Downloads
References
1. Kanakamedala AC, Hurley ET, Manjunath AK, Jazrawi LM, Alaia MJ, Strauss EJ. High tibial osteotomies for the treatment of osteoarthritis of the knee. JBJS Rev. 2022;10(1):e21.00127. https://doi.org/10.2106/JBJS.RVW.21.00127 PMID: 35020711.
2. Brouwer RW, Huizinga MR, Duivenvoorden T, van Raaij TM, Verhagen AP, Bierma-Zeinstra SMA, Verhaar JAN. Osteotomy for treating knee osteoarthritis. Cochrane Database Syst Rev. 2014;(12):CD004019. https://doi.org/10.1002/14651858.CD004019.pub4 PMID: 25503775; PMCID: PMC7173694
3. Sharma L, Song J, Felson DT, Cahue S, Shamiyeh E, Dunlop DD. The role of knee alignment in disease progression and functional decline in knee osteoarthritis. JAMA. 2001;286(2):188-95. https://doi.org/10.1001/jama.286.2.188 PMID: 11448282.
4. Coventry MB. Osteotomy of the upper portion of the tibia for degenerative arthritis of the knee. A preliminary report. J Bone Joint Surg Am. 1965;47:984-90. PMID: 14318636.
5. Lobenhoffer P, Agneskirchner JD. Improvements in surgical technique of valgus high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2003;11(3):132-8. https://doi.org/10.1007/s00167-002-0334-7 PMID: 12774149.
6. Belsey J, Yasen SK, Jobson S, Faulkner J, Wilson AJ. Return to physical activity after high tibial osteotomy or unicompartmental knee arthroplasty: a systematic review and pooling data analysis. Am J Sports Med. 2021;49(5):1372-80. https://doi.org/10.1177/0363546520948861 PMID: 32960075; PMCID: PMC8020302.
7. Hoorntje A, Kuijer PPFM, van Ginneken BT, Koenraadt KLM, van Geenen RCI, Kerkhoffs GMMJ, van Heerwaarden RJ. Prognostic factors for return to sport after high tibial osteotomy: a directed acyclic graph approach. Am J Sports Med. 2019;47(8):1854-62. https://doi.org/10.1177/0363546519849476 PMID: 31157542; PMCID: PMC6604251.
8. Ekhtiari S, Haldane CE, de Sa D, Simunovic N, Musahl V, Ayeni OR. Return to work and sport following high tibial osteotomy: a systematic review. J Bone Joint Surg Am. 2016;98(18):1568-77. https://doi.org/10.2106/JBJS.16.00036 PMID: 27655985.
9. Hoorntje A, Witjes S, Kuijer PPFM, Koenraadt KLM, van Geenen RCI, Daams JG, Getgood A, Kerkhoffs GMMJ. High rates of return to sports activities and work after osteotomies around the knee: a systematic review and meta-analysis. Sports Med. 2017;47(11):2219-44. https://doi.org/10.1007/s40279-017-0726-y PMID: 28401426; PMCID: PMC5633634.
10. Kunze KN, Beletsky A, Hannon CP, LaPrade RF, Yanke AB, Cole BJ, et al. Return to work and sport after proximal tibial osteotomy and the effects of opening versus closing wedge techniques on adverse outcomes: a systematic review and meta-analysis. Am J Sports Med. 2020;48(9):2295-304. https://doi.org/10.1177/0363546519881638 PMID: 31774691.
11. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. https://doi.org/10.1136/bmj.n71 PMID: 33782057; PMCID: PMC8005924.
12. Moons KGM, de Groot JAH, Bouwmeester W, Vergouwe Y, Mallett S, Altman DG, Reitsma JB, Collins GS. Critical appraisal and data extraction for systematic reviews of prediction modelling studies: the CHARMS checklist. PLoS Med. 2014;11(10):e1001744. https://doi.org/10.1371/journal.pmed.1001744 PMID: 25314315; PMCID: PMC4196729.
13. Wan X, Wang W, Liu J, Tong T. Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range. BMC Med Res Methodol. 2014;14:135. https://doi.org/10.1186/1471-2288-14-135 PMID: 25524443; PMCID: PMC4383202.
14. Hayden JA, van der Windt DA, Cartwright JL, Côté P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158(4):280-6. https://doi.org/10.7326/0003-4819-158-4-201302190-00009 PMID: 23420236.
15. Campbell M, McKenzie JE, Sowden A, Katikireddi SV, Brennan SE, Ellis S, et al. Synthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline. BMJ. 2020;368:l6890. https://doi.org/10.1136/bmj.l6890 PMID: 31948937; PMCID: PMC7190266.
16. Iorio A, Spencer FA, Falavigna M, Alba C, Lang E, Burnand B, et al. Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients. BMJ. 2015;350:h870. https://doi.org/10.1136/bmj.h870 PMID: 25775931.
17. Katagiri H, Shioda M, Nakagawa Y, Ohara T, Ozeki N, Nakamura T, Sekiya I, Koga H. Risk factors affecting return to sports and patient-reported outcomes after opening-wedge high tibial osteotomy in active patients. Orthop J Sports Med. 2022;10(9):23259671221118836. https://doi.org/10.1177/23259671221118836 PMID: 36199825; PMCID: PMC9528023.
18. Kanto R, Nakayama H, Iseki T, Onishi S, Ukon R, Kanto M, Kambara S, Yoshiya S, Tachibana T. Return to sports rate after opening wedge high tibial osteotomy in athletes. Knee Surg Sports Traumatol Arthrosc. 2021;29(2):381-88. https://doi.org/10.1007/s00167-020-05967-w PMID: 32248273.
19. Lucidi GA, Di Paolo S, Adravanti FM, Maitan N, Dal Fabbro G, Naldi F, Grassi A, Zaffagnini S. Kinesiophobia and high-impact sport activity are associated with a reduced rate of return to sport after high tibial osteotomy: a risk factor analysis of a young and active population. Am J Sports Med. 2025;53(5):1068-76. https://doi.org/10.1177/03635465251322795 PMID: 40070113.
20. Maeda S, Chiba D, Sasaki E, Oyama T, Sasaki T, Otsuka H, Ishibashi Y. The difficulty of continuing sports activities after open-wedge high tibial osteotomy in patient with medial knee osteoarthritis: a retrospective case series at 2-year-minimum follow-up. J Exp Orthop. 2021;8(1):68. https://doi.org/10.1186/s40634-021-00385-4 PMID: 34435240; PMCID: PMC8387523.
21. de Geofroy B, Chateau L, Barbier O, Demoures T, Coste S, Mathieu L, de L’Escalopier N, Choufani C. Return to sport and duty in French military personnel after medial opening wedge high tibial osteotomy. Mil Med. 2024;189(11-12):2488-93. https://doi.org/10.1093/milmed/usae005 PMID: 38294141.
22. Jacquet C, Gulagaci F, Schmidt A, Pendse A, Parratte S, Argenson JN, Ollivier M. Opening wedge high tibial osteotomy allows better outcomes than unicompartmental knee arthroplasty in patients expecting to return to impact sports. Knee Surg Sports Traumatol Arthrosc. 2020;28(12):3849-57. https://doi.org/10.1007/s00167-020-05857-1 PMID: 32008058.
23. Nicolini AP, Christiano ES, Abdalla RJ, Cohen M, de Carvalho RT. Return to sports after high tibial osteotomy using the opening wedge technique. Rev Bras Ortop (Sao Paulo). 2021;56(3):313-9. https://doi.org/10.1055/s-0040-1715514 PMID: 34239195; PMCID: PMC8249055.
24. De Neve F, Braems B, Holvoet M, De Scheerder MA, Arnout N, Victor J. Return to sport and work after medial open wedge high tibial osteotomy: a case series. Acta Orthop Belg. 2021;87(1):117-24. PMID: 34129765.
25. Kawashima F, Oike J, Segami K, Kanzaki K. Preoperative activity, postoperative flexion contractures, and degree of medial cartilage damage affects achievement of high physical activity after open wedge high tibial osteotomy. J Exp Orthop. 2025;12(3):e70372. https://doi.org/10.1002/jeo2.70372 PMID: 40708885; PMCID: PMC12287782.
26. Guo H, Li Q, Zhang Z, Feng A, Qin S, Liu L, Sun R, Wang X. Better clinical outcomes and return to sport rates with additional medial meniscus root tear repair in high tibial osteotomy for medial compartmental knee osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2024;32(7):1753-65. https://doi.org/10.1002/ksa.12180 PMID: 38643405.
27. Donelon TA, Dos’Santos T, Pitchers G, Brown M, Jones PA. Biomechanical determinants of knee joint loads associated with increased anterior cruciate ligament loading during cutting: a systematic review and technical framework. Sports Med Open. 2020;6(1):53. https://doi.org/10.1186/s40798-020-00276-5 PMID: 33136207; PMCID: PMC7606399.
28. Lee LS, Chan PK, Fung WC, Chan VWK, Yan CH, Chiu KY. Imaging of knee osteoarthritis: a review of current evidence and clinical guidelines. Musculoskeletal Care. 2021;19(3):363-74. https://doi.org/10.1002/msc.1536 PMID: 33387447.
29. Kellgren JH, Lawrence JS. Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494-502. https://doi.org/10.1136/ard.16.4.494 PMID: 13498604; PMCID: PMC1006995.
30. Nakayama H, Schröter S, Yamamoto C, Iseki T, Kanto R, Kurosaka K, Kambara S, Yoshiya S, Higa M. Large correction in opening wedge high tibial osteotomy with resultant joint-line obliquity induces excessive shear stress on the articular cartilage. Knee Surg Sports Traumatol Arthrosc. 2018;26(6):1873-8. https://doi.org/10.1007/s00167-017-4680-x PMID: 28831525.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 The Author (s).

This work is licensed under a Creative Commons Attribution 4.0 International License.
| Article metrics | |
|---|---|
| Abstract views | |
| Galley vies | |
| PDF Views | |
| HTML views | |
| Other views | |











